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Clinical Research Studies

The Pendleton Eye Center has been participating in national clinical trials since 2006, primarily in the areas of dry eye disease, inflammation, and infection. Our team is most often involved in phase III clinical trials, which compare the safety and effectiveness of the new treatment against the current standard treatment. Past trials have included Upneeq, the now FDA approved treatment for droopy eye lids; Eysuvis, the now FDA approved short-term treatment for dry eye, as well as a number of phase III trials for pain and inflammation post cataract surgery.

Sponsoring agencies have included the National Institutes for Health and leading ophthalmic pharmaceutical companies such as Bausch and Lomb, Allergan and Alcon.  We have also assisted non-ophthalmic research studies by performing in-depth ophthalmic evaluations of patients receiving oral medications for a variety of non-ophthalmic disorders, and Dr. Pendleton has been trained in the LOCS III method of cataract classification.

Participating in clinical trials has benefited our office in many ways.  As part of the clinical research process, our records, equipment, and internal processes are scrutinized by regulatory agencies including the FDA, independent clinical research specialists, the pharmaceutical industry, and peer clinical research associates ensuring that we adhere to the highest standards of quality and reproducibility, and that we maintain the utmost integrity. Dr. Robert Pendleton’s primary mandate is to ensure patient safety, and this serves as an important reminder of the sage physician adage of “first, do no harm.”  The oversite and self-reflection necessary to adhere to strict clinical research standards adds to our professionalism, enhances our patient-oriented focus, and serves as an acknowledgment of our dedication to excellence in patient care. 

Kowa Pharmaceuticals Phase 3 trial for Corneal Edema Post Cataract Surgery. (Enrollment closed)

You are invited to participate in this study if you are 18 years old or older, have been diagnosed with a Cataract and are planning to have Cataract Surgery.

The study is being conducted by Dr. Robert Pendleton at Pendleton Eye Center located in Oceanside, CA.

  • Dr. Robert Pendleton will examine you to see if you are qualified to take part in the study.
  • If eligible, you will receive compensation for your time based on each visit you complete.
  • If eligible, there will be up to 9 scheduled in-person visits and 2 telephone visits.

For more information, or if you are interested in participating in the study, please contact the study coordinator: Debbie McClusky Phone: 760-758-2008 or email:

Currently Enrolling: Kowa Pharmaceuticals Phase 3 Trial for Dry Eye.

If you have a diagnosis of dry eye disease, you may potentially be eligible for participation in this study.

The purpose of the study is to see how safe and effective eye drops containing an investigational drug are in the treatment of dry eye disease as compared to a placebo.

  • An investigational drug is one that has not been approved by the Food and Drug Administration [FDA] but may be used in research studies.
  • A placebo means that the product (eye drop) does not have any medicine in it.

Both the study drug and the placebo are given as eye drops in this  study. The first 300 subjects randomized will participate for 52 weeks (9 in-clinic visits) and the  last 320 subjects randomized will participate for 12 weeks (6 in-clinic visits) at our clinic in Oceanside, CA. The study drug is administered twice daily.

The study is completely voluntary. As part of the research study, participants will receive eye exams and study medication at no charge, and you may receive compensation for your time. If  you are interested in learning if you meet the eligibility requirements to participate or would like to know more about the study, please contact us at (760) 758-2008.

Thank you for your time and interest.


Please contact our Research Coordinator, Debra McCluskey at extension 6, for more information on current clinical research studies.  A comprehensive list of clinical research studies can also be found at The National Institute of Health and, a resource provided by the U.S. National Library of Medicine.

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Oceanside, CA 92056

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